Several types of epidemiological research have shown the importance of genetic factors to the emergence of diseases.
1. Research on the "migration" groups of residents revealed that despite living in countries with a particular predisposition of some disease, the population of other ethnic groups that settled in and for generations are living in those countries, they maintained the frequency of the disease that is characteristic for the countries from which they migrated from. Thus, in England, was found a very low frequency of RA among the Caribbean population and of Pakistani origin, which is significantly smaller than those in English domicile population.
2. Family grouping of the disease. It is estimated that the appearance of RA is about 2 times more frequent in family members. However, it is considerably less than in other chronic diseases such as diabetes or multiple sclerosis.
3. Research on twins has shown that 50-60% incidence of the disease in both twins may be explained by their common genetic characteristics. Today, there are some known genes responsible for disease, such as HLA DRB1 and HLA DRB1 * 0404, which is estimated to have been responsible for about 50% of the genetic effects of related to RA.
1. Research on the "migration" groups of residents revealed that despite living in countries with a particular predisposition of some disease, the population of other ethnic groups that settled in and for generations are living in those countries, they maintained the frequency of the disease that is characteristic for the countries from which they migrated from. Thus, in England, was found a very low frequency of RA among the Caribbean population and of Pakistani origin, which is significantly smaller than those in English domicile population.
2. Family grouping of the disease. It is estimated that the appearance of RA is about 2 times more frequent in family members. However, it is considerably less than in other chronic diseases such as diabetes or multiple sclerosis.
3. Research on twins has shown that 50-60% incidence of the disease in both twins may be explained by their common genetic characteristics. Today, there are some known genes responsible for disease, such as HLA DRB1 and HLA DRB1 * 0404, which is estimated to have been responsible for about 50% of the genetic effects of related to RA.
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